A2M (Alpha-2-Macroglobulin) is a protein that naturally occurs in plasma that blocks proteins that are responsible for creating arthritis in the body. By harvesting a patient’s A2M and re-injecting the super concentrated A2M mixture into the diseased joint, the progression of arthritis (specifically osteoarthritis) can be stopped as well as preventing further loss of cartilage, promoting tissue growth and relief from inflammation/pain.

How it Works

The body naturally produces protein classes that degrade cartilage when the joint is injured. A2M is a powerful inhibitor of three specific protein classes that cause cartilage to breakdown: Cytokines, Matrix Metalloproteinases and A Disintegrin and Metalloproteinase with Thrombospondin. By blocking these proteins, A2M injections can stop the progression of Osteoarthritis (once those proteins are trapped the body can eliminate them quickly) as well as support cartilage restoration.

The Procedure

Blood is collected from the patient and then processed using an Alpha 2 Macroglobulin concentrator with a centrifuge and filtration system. The super concentrated amount of A2M is now ready to be injected into the patient’s affected joint using ultrasound guidance.

Healing Process

After the procedure, the patient will experience minimal discomfort for 3-5 days. Patients may begin to experience pain relief in 4-6 weeks. Patients are monitored by the doctor until the patient can completely return to pre-procedural activities. The regenerative process continues to work over a period of 6 months to a year with most patients continuing to improve in function/movement and decreasing in inflammation/pain.


  • Helps restore the joint affected by Osteoarthritis
  • Prevents the progression of arthritis
  • Can be used to treat low back pain, degenerative discs, soft tissues and inflammation
  • Stops pain and inflammation in the joint